Diseases and disorders which affect the lymphatic system

Many conditions can affect the vessels, glands, and organs that make up the lymphatic system. Some happen during development before birth or during childhood. Others develop as a result of disease or injury. Some common and less common diseases and disorders of the lymphatic system include:

Here the list of Diseases and disorders which affect the lymphatic system:

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Enlarged (swollen) lymph nodes (lymphadenopathy)

Enlarged lymph nodes are caused by infection, inflammation or cancer. Common infections that can cause enlarged lymph nodes include strep throat, mononucleosis, HIV infection and infected skin wounds. Lymphadenitis refers to lymphadenopathy that is caused by an infection or inflammatory condition.

Swelling or accumulation of fluid (Lymphedema)

Lymphedema can result from a blockage in the lymphatic system caused by scar tissue from damaged lymph vessels or nodes. Lymphedema is also often seen when lymph nodes are removed from those who’ve had surgery or radiation to remove cancer.

The buildup of lymphatic fluid is most commonly seen in your arms and legs. Lymphedema can be very mild or be quite painful, disfiguring and disabling. People with lymphedema are at risk for serious and potentially life-threatening deep skin infections.

Cancers of the lymphatic system

Lymphoma is cancer of the lymph nodes and occurs when lymphocytes grow and multiply uncontrollably. There are several different types of lymphoma, including Hodgkin’s lymphoma and non-Hodgkin’s lymphoma.

Cancerous tumors can also block lymphatic ducts or be near lymph nodes and interfere with the flow of lymph through the node.

Disorder which affect lymphatic system


This is an inflammation of the lymph vessels.


This is a condition that you’re born with. It’s a malformation in the lymphatic system. Lymphangiomatosis is the presence of multiple or widespread lymphatic vascular malformations.

Intestinal lymphangiectasia

This is a condition in which loss of lymph tissue in the small intestine leads to loss of protein, gammaglobulins, albumin and lymphocytes.


This is a condition in which there is a higher-than-normal amount of lymphocytes in the body.

Lymphatic filariasis

This is an infection caused by a parasite that causes the lymphatic system not to function correctly.

Castleman disease

 Castleman disease involves an overgrowth of cells in the body’s lymphatic system.


This is a rare lung disease in which abnormal muscle-like cells begin to grow out of control in the lungs, lymph nodes and kidneys.

Autoimmune lymphoproliferative syndrome

This is a rare genetic disorder in which there is a high number of lymphocytes in the lymph nodes, liver and spleen.

Mesenteric lymphadenitis

This is an inflammation of the lymph nodes in the abdomen.


This is an inflammation and infection of the tonsils.

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